Yan Geng Selected Research

Cyclins

1/2022	CDK4 and CDK6 kinases: From basic science to cancer therapy.
1/2021	Cyclin E in normal physiology and disease states.
10/2020	The requirement for cyclin E in c-Myc overexpressing breast cancers.
7/2019	Author Correction: Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
1/2018	Kinase-independent function of E-type cyclins in liver cancer.
1/2018	Cyclin D-CDK4 kinase destabilizes PD-L1 via cullin 3-SPOP to control cancer immune surveillance.
1/2017	The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival.
4/2013	Differences in regulation and function of E-cyclins in human cancer cells.
8/2008	Peroxisome proliferator-activated receptor-delta induces cell proliferation by a cyclin E1-dependent mechanism and is up-regulated in thyroid tumors.
12/2003	Requirement for cyclin D3 in lymphocyte development and T cell leukemias.

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Yan Geng Research Topics

Disease

49	Neoplasms (Cancer) 01/2022 - 12/2003
12	Carcinogenesis 01/2022 - 12/2003
9	Inflammation (Inflammations) 10/2022 - 02/2015
9	Rheumatoid Arthritis 03/2022 - 10/2012
9	Neoplasm Metastasis (Metastasis) 11/2021 - 09/2008
8	Fibrosis (Cirrhosis) 01/2022 - 01/2014
7	Liver Cirrhosis (Hepatic Cirrhosis) 01/2022 - 03/2016
7	Colorectal Neoplasms (Colorectal Cancer) 11/2021 - 07/2009
6	Breast Neoplasms (Breast Cancer) 10/2020 - 08/2002
4	Hepatocellular Carcinoma (Hepatoma) 11/2021 - 01/2018
3	Idiopathic Thrombocytopenic Purpura (Thrombocytopenic Purpura, Autoimmune) 12/2022 - 06/2019
3	Thrombocytopenia (Thrombopenia) 12/2022 - 12/2018
3	Body Weight (Weight, Body) 10/2022 - 08/2009
3	Synovitis 03/2022 - 08/2014
3	Ulcerative Colitis 12/2021 - 12/2010
3	Insulin Resistance 04/2021 - 12/2019
3	Colonic Neoplasms (Colon Cancer) 01/2021 - 01/2010
3	COVID-19 01/2021 - 11/2020
3	Carcinoma (Carcinomatosis) 10/2020 - 01/2006
3	Non-alcoholic Fatty Liver Disease 12/2019 - 01/2017
3	Heat Stroke (Heatstroke) 11/2019 - 02/2015
3	Lung Neoplasms (Lung Cancer) 01/2015 - 04/2008
2	Obesity 10/2022 - 01/2021
2	Nephritis 02/2022 - 01/2018
2	Rheumatic Diseases (Rheumatism) 01/2022 - 02/2017
2	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2021 - 08/2020
2	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 09/2021 - 07/2005
2	Anemia 01/2021 - 08/2004
2	Sepsis (Septicemia) 01/2021 - 02/2015
2	Infections 01/2021 - 04/2018
2	Liver Diseases (Liver Disease) 09/2020 - 09/2019
2	Pancreatic Neoplasms (Pancreatic Cancer) 03/2020 - 05/2018
2	Uterine Cervical Neoplasms (Cancer of the Cervix) 11/2019 - 07/2011
2	Multiple Myeloma 12/2018 - 01/2018
2	Adenocarcinoma 05/2018 - 07/2011
2	Pain (Aches) 01/2018 - 10/2015
2	Colitis 01/2018 - 01/2016
2	Lung Injury 12/2017 - 11/2016
2	Pulmonary Fibrosis (Fibrosing Alveolitis) 11/2016 - 02/2015
2	BCR-ABL Positive Chronic Myelogenous Leukemia (Chronic Myelogenous Leukemia) 02/2016 - 11/2014

Drug/Important Bio-Agent (IBA)

20	Proteins (Proteins, Gene)FDA Link 01/2022 - 12/2003
10	CyclinsIBA 01/2022 - 12/2003
8	Phosphotransferases (Kinase)IBA 01/2022 - 01/2006
6	Biological ProductsIBA 11/2020 - 08/2014
5	DNA (Deoxyribonucleic Acid)IBA 12/2019 - 07/2011
5	Cyclin D1IBA 01/2014 - 08/2004
4	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2022 - 01/2017
4	Biomarkers (Surrogate Marker)IBA 01/2021 - 01/2009
4	Cyclin EIBA 01/2021 - 08/2007
4	MicroRNAs (MicroRNA)IBA 01/2020 - 04/2016
4	GenisteinIBA 03/2017 - 10/2005
4	Interleukin-6 (Interleukin 6)IBA 03/2017 - 07/2005
3	Interleukin-10 (Interleukin 10)IBA 12/2021 - 06/2019
3	CytokinesIBA 10/2021 - 02/2015
3	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 08/2021 - 01/2016
3	Immune Checkpoint InhibitorsIBA 02/2021 - 01/2018
3	FollistatinIBA 01/2020 - 04/2013
3	LipidsIBA 12/2019 - 08/2008
3	Translationally-Controlled 1 Tumor ProteinIBA 10/2018 - 01/2010
3	rakicidinsIBA 05/2018 - 11/2014
3	Surface-Active Agents (Surfactants)IBA 11/2016 - 01/2006
3	Soybean Proteins (Soy Protein)IBA 05/2007 - 06/2005
3	Caseins (Casein)FDA Link 10/2005 - 12/2004
2	LipopolysaccharidesIBA 10/2022 - 01/2017
2	EndotoxinsIBA 10/2022 - 11/2012
2	GlucocorticoidsIBA 04/2022 - 01/2021
2	Toll-Like Receptor 4IBA 03/2022 - 01/2017
2	UbiquitinIBA 03/2022 - 01/2010
2	Dopamine D3 ReceptorsIBA 03/2022 - 10/2018
2	Hormones (Hormone)IBA 01/2022 - 01/2021
2	GlycosidesIBA 01/2022 - 01/2015
2	Becaplermin (PDGF-BB)FDA Link 01/2022 - 01/2017
2	Therapeutic UsesIBA 09/2021 - 12/2010
2	Cisplatin (Platino)FDA LinkGeneric 09/2021 - 01/2015
2	Saline SolutionIBA 04/2021 - 10/2015
2	Blood Glucose (Blood Sugar)IBA 04/2021 - 01/2020
2	fibrin fragment D (D-dimer)IBA 01/2021 - 11/2020
2	Antirheumatic Agents (DMARD)IBA 01/2021 - 08/2014
2	InterleukinsIBA 01/2021 - 01/2016
2	Glucose (Dextrose)FDA LinkGeneric 01/2020 - 12/2019
2	Neutralizing AntibodiesIBA 01/2020 - 02/2015
2	Insulin (Novolin)FDA Link 01/2020 - 12/2019
2	Cell-Free Nucleic AcidsIBA 11/2019 - 07/2011
2	Inosine Triphosphate (ITP)IBA 08/2019 - 06/2019
2	EnzymesIBA 08/2019 - 01/2017
2	Ethanol (Ethyl Alcohol)IBA 01/2019 - 01/2016
2	Cadherins (E-Cadherin)IBA 01/2019 - 05/2007
2	LigandsIBA 01/2019 - 01/2018
2	Bleomycin (Blenoxane)FDA LinkGeneric 01/2019 - 02/2015
2	InflammasomesIBA 01/2019 - 09/2015
2	Hyaluronic Acid (Hyaluronan)IBA 01/2019 - 11/2016
2	HMGB1 Protein (HMG1)IBA 10/2018 - 09/2015
2	Cyclin-Dependent Kinase 2IBA 01/2018 - 08/2007
2	Dextran SulfateIBA 01/2018 - 01/2016
2	Nitric Oxide (Nitrogen Monoxide)FDA Link 03/2017 - 01/2016
2	Transcription Factors (Transcription Factor)IBA 01/2016 - 08/2007
2	Indicators and Reagents (Reagents)IBA 01/2015 - 03/2012

Therapy/Procedure

20	Therapeutics 12/2022 - 12/2010
3	Immunotherapy 11/2021 - 09/2019
2	Drug Therapy (Chemotherapy) 01/2015 - 03/2012